Discovery scientist in Transcriptional regulation

Basel, Basel-Stadt, ch
Company: myGwork
Category: Life, Physical, and Social Science Occupations
Published on 2021-06-24 04:13:21

At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are ambitious in both decision and action. And we believe that good business means a better world. That is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

Within Roche’s Pharma Research and Early Development (pRED), Neuroscience & Rare Diseases represents a major focus area where we are committed to realizing our long-term vision of changing lives of patients with severe brain disorders. Our research and early development activities center around large and rare indications within the four major pillars of neurodevelopmental disorders, movement disorders, dementias, and multiple sclerosis. With strengths across diverse disciplines, Roche is uniquely positioned to lead in transforming science to medicines for patients with disorders of the nervous system.

To achieve our goals, Roche pRED Neuroscience & Rare Diseases is currently undergoing a major and exciting recruitment effort for a large number of new positions including a Discovery Scientist in Transcriptional Regulation within the Neurogenomics Section in the Department of Research. All positions are based in Basel, Switzerland.

 

The position

We are seeking a highly motivated and collaborative Scientist to join the Transcriptional Regulation laboratory within the Neurogenomics section to investigate gene regulatory elements, mechanisms of post-transcriptional gene regulation and their relationship to human brain disorders. Neurogenomics in the Neuroscience and Rare Disease (NRD ) research department spans the interface of human genetics, single cell genomics, functional genomics, molecular biology, and advanced computational methodology. In this role, you will be joining a team of researchers working at the cutting edge of human genetics and functional genomics in a highly collaborative environment to identify new therapeutic hypotheses for target identification and target validation to build and advance transformative medicines for neurodevelopmental disorders, dementia, movement disorders and multiple sclerosis.

You will work on investigating the role of gene regulatory sequences and post-transcriptional mechanisms in neurobiology and disease. Through a combination of genomic technologies, human patient samples, hiPSC cellular engineering technologies, and massively parallel reporter assays (MPRA), you will be leading efforts to target gene regulatory and transcriptional mechanisms as potential therapeutic targets for neurological disorders caused by haploinsufficient genes. 

The successful candidate will contribute to the creation and advancement of genomic medicines across our NRD pipeline. This is a highly collaborative, hands-on position at the interface of discovery and translational research activities. The position requires adaptability, creativity, and a capacity for constant innovation in pursuit of the NRD vision and goals. The environment is exciting, fast-paced and offers the opportunity to work and publish at the cutting edge of cellular engineering research.

Your main responsibilities

  • Perform research centered on developing new therapeutic approaches to precisely target RNA (via splice modifiers, base editing, translation upregulation) and DNA (cis regulation via targeting enhancers) of haploinsufficient neurodevelopmental and neurodegenerative disease genes to upregulate the expression levels of the target genes and rescue disease phenotypes in relevant human cellular models.

  • Develop massively parallel reporter assays (MRPAs) to characterize thousands of gene regulatory sequences of high-confidence disease risk genes identified from in house and publicly available brain genomics datasets to test their regulatory activity in disease relevant human cellular models

  • Collaborate with scientists and research associates in the NRD neurotechnologies laboratory and in other pRED functions to develop CNS cell type specific promoters and enhancers for viral and non-viral based CNS gene therapy delivery  

  • Perform, analyze and document experimental laboratory procedures with exceptional attention to detail

  • Effectively analyze and present data internally and externally

  • Manage and support research studies with academic partners and/or contract research organizations

  • Publish in peer reviewed journals; contribute to scientific research papers and reports

Who you are

Essential

  • PhD in neuroscience, molecular biology, biochemistry, genetics or related discipline, with 2 – 5+ years of relevant industry or post-doctoral experience. Level will be determined by experience and skills

  • Expertise in molecular biology including cloning, quantitative PCR, and next generation sequencing methods and mammalian tissue culture, preferably primary and iPSC-derived neurons and glia.

  • Experience with high throughput assay design and implementation of gene regulatory elements reporter assay.

  • Strong record of independent research and publication in peer-reviewed journals.

  • Excellent oral and written communication skills, and able to thrive in high functioning team environments.

Desirable

  • Experience working with CRISPR/Cas, siRNA, ASOs gene regulation technologies.

  • Experience working on rare neurodevelopmental and neurodegenerative disorders..

  • Experience in gene therapy and working knowledge of AAV.

Are you ready to apply? Roche embraces diversity and equal opportunity in a serious way. We are committed to building teams that represents a range of backgrounds, perspectives, and skills. 

If you still have questions then please check our FAQs and videos on careers.roche.ch/faq.

For non-EU / EFTA citizens: Please state your eligibility status to work in Switzerland (e.g. B-Permit, C-Permit) and note that if you do not own a valid Swiss work permit, Roche cannot guarantee your final employment due to authority regulations.

This employer is a corporate member of myGwork, the business community for LGBTQ+ professionals, graduates, inclusive employers & anyone who believes in workplace equality.

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