ADME Scientist

Basel, Basel-Stadt, ch
Company: Global Personal Partner AG
Category: Architecture and Engineering Occupations
Published on 2021-06-21 04:07:21
Our profession and our passion "HR Management."Global Personal is an independent company of the Interiman Group SA with over 100 employees offering a complete range of human resources services at 21 locations in German-speaking Switzerland

For our client, an international orientated chemical company, we are looking for a reliable and motivated (m/f/x)  ADME Scientist

Working principally on small molecule projects, we are looking for a motivated candidate to fill the gaps in the ADME field for drug development. A position is available for a 1-year contractor to work on advancing in vitro assay techniques to estimate fractions metabolized by enzymes to support clinical PK prediction and drug-drug interaction (DDI) risk assessment for small molecules portfolios.

Aufgabenbeschreibung

The perfect candidate has a PhD or Post Doc (Master are accepted but a higher education is much preferred). This person should have expert knowledge of bioanalytics and in vitro enzyme assays. The ideal would be for this person to have already working knowledge of LCMS & of the Sciex software. We are looking for between 3 to 5 years' experience minimum with experience in industry. The experience in industry is necessary because part of the responsibilities will be regulatory guidelines alignment. 

On a soft skills note, the team is looking for someone with strong communication skills, the ability to work in a fast-paced and quickly changing environment in close collaboration with partner functions. Proficient in English is required; ability to communicate in German is an asset. 


General Information:

  • Start date: Mid-April / early May 
  • Latest start date: 1 month of notice period max
  • End date: 1 year duration
  • Extension: not planned at the moment

  • Work location: BS
  • Workload: 100%
  • Travelling: no
  • Team: Around 5 people


  • Tasks & Responsibilities:

  • Conduct the laboratory work in enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes

  • Analyzing incubation samples via LC-MS/MS and radio-HPLC, including the method development and/or validation.
  • Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and in drug development setting reporting to the respective laboratory staff and supervisors.

  • Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.

  • Some time may be spent on supporting to develop new enzyme phenotyping methodologies and approaches.


  • Erforderliches Profil

  • PhD or Post Doc in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD) (Master are considered but higher education is preferred)

  • Min 3/5 years of experience in similar position

  • Experience in bioanalysis & in vitro assays

  • Experience in industry

  • Excellent knowledge of metabolic enzyme biochemistry (e.g. CYP, UGT), kinetics assessment and the respective experimental designs.

  • You have a strong interest in translational approaches leveraging in vitro data and clinical data


  • Nice to haves:

  • Competence in method development/validation for radio-HPLC (e.g. Thermo) and LC-MS/MS (e.g. Sciex). This includes troubleshooting and data analysis (e.g. Analyst). Please note here experience with “Sciex” is really highly valued. 

  • Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies)

     
  • We offer you an interesting and varied job in a company rich in tradition and managed according to modern principles. You will carry out your tasks in an extremely international environment.


    Are you interested?
    Our recruiter Noemi Käslin is looking forward to receiving your complete electronic application (CV, certificates, diplomas).

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